Introduction to Biochemical Toxicology
Third Edition
Over the past several decades, biochemical toxicology has contributed greatly to the advancement of scientific disciplines ranging from medicine and pharmacology to environmental science and industrial hygiene. In its never-ending quest to define the biochemical, cellular, and molecular events occurring when toxicants interact with organisms, biochemical toxicology provides the rational basis for, among other things, our understanding of acute and chronic toxic processes, the development of new therapies, the determination of toxic hazards, and the development of medical and agricultural biocides.
Recent applications of new molecular and cellular techniques have greatly expanded our knowledge of how toxicants produce their adverse effects. As a consequence, the time has come for a substantial revision of Professor Ernest Hodgson's classic reference in the field. This Third Edition now contains updated overview chapters on immunochemical and molecular techniques. It also features entirely new chapters covering such crucial topics as immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology.

Biochemical Toxicology: Definition and Scope (E. Hodgson & R. Smart).

Overview of Molecular Techniques in Toxicology: Genes/Transgenes (R. Smart).

Immunochemical Techniques in Toxicology (G. LeBlanc).

Overview of Cellular Techniques in Toxicology (S. Meyer).

Metabolism of Toxicants: Phase I Reactions and Pharmacogenetics (E. Hodgson & J. Goldstein).

Conjugation and Elimination of Toxicants (G. LeBlanc & W. Dauterman).

Physiological Factors Affecting Xenobiotic Metabolism (M. Ronis & H. Cunny).

Adaptation to Toxicants (R. Rose & E. Hodgson).

Reactive Metabolities and Toxicity (P. Levi & E. Hodgson).

Mechanisms of Chemically Induced Cell Injury and Cellular Protection Mechanisms (D. Reed).

Nutritional Factors (W. Donaldson).

Toxicant-Receptor Interactions: Fundamental Principles (R. Mailman & C. Lawler).

Effects of Toxicants on Electron Transport and Oxidative Phosphorylation (D. Moreland).

Effects of Toxicants on Nucleic Acid and Protein Metabolism (D. Holbrook).

Carcinogenesis (R. Smart & J. Akunda).

Genetic Toxicology.

Molecular Epidemiology (M. Stern, et al.).

Biochemical Toxicology of the Pheripheral Nervous System (P. Morell, et al.).

Biochemical Toxicology of the Central Nervous System (B. Blake, et al.).

Hepatotoxicity (S. Meyer & A. Kulkarni).

Dermatotoxicology (N. Monteiro-Riviere).

Reproductive and Developmental Toxicity (S. Branch).

Immunotoxicity (M. Selgrade, et al.).

Respiratory Tract Toxicity (R. Henderson & K. Nikula).

Biochemical Mechanisms of Renal Toxicity (J. Tarloff).

Cardiovascular Toxicity (A. Combs, et al.).

Suggested Reading.